Ronald E Viola Selected Research

aspartoacylase

1/2020	Development of bisubstrate analog inhibitors of aspartate N-acetyltransferase, a critical brain enzyme.
11/2014	Enhanced brain distribution of modified aspartoacylase.
8/2014	Aspartoacylase catalytic deficiency as the cause of Canavan disease: a structural perspective.
1/2013	Relationship between enzyme properties and disease progression in Canavan disease.
2/2011	Modification of aspartoacylase for potential use in enzyme replacement therapy for the treatment of Canavan disease.
3/2008	Examination of the mechanism of human brain aspartoacylase through the binding of an intermediate analogue.
5/2006	Characterization of human aspartoacylase: the brain enzyme responsible for Canavan disease.

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Ronald E Viola Research Topics

Disease

12	Canavan Disease (Leukodystrophy, Spongiform) 01/2021 - 05/2006
10	Nervous System Diseases (Neurological Disorders) 01/2021 - 05/2006
2	Mycoses (Diseases, Fungus) 01/2020 - 01/2018
1	COVID-19 01/2021
1	Virus Diseases (Viral Diseases) 01/2021
1	Neoplasms (Cancer) 12/2017
1	Tinea (Ringworm) 02/2016
1	Demyelinating Diseases (Demyelinating Disease) 01/2013
1	Disease Progression 01/2013
1	Acquired Immunodeficiency Syndrome (AIDS) 06/2010
1	Plague (Bubonic Plague) 05/2008
1	Human Influenza (Influenza) 06/2002

Drug/Important Bio-Agent (IBA)

9	EnzymesIBA 01/2020 - 05/2006
7	aspartoacylaseIBA 01/2020 - 05/2006
4	Pharmaceutical PreparationsIBA 01/2020 - 02/2016
4	N-acetylaspartate (N-acetyl aspartate)IBA 01/2017 - 03/2008
3	Aspartic Acid (Aspartate)FDA Link 08/2014 - 03/2008
2	aspartate N-acetyltransferaseIBA 01/2020 - 01/2017
1	Amino Acids FDA Link 01/2021
1	Antiviral Agents (Antivirals)IBA 01/2021
1	Neurotransmitter Agents (Neurotransmitter)IBA 01/2021
1	S-Adenosylmethionine (Ademetionine)IBA 12/2017
1	Anti-Infective Agents (Microbicides)IBA 12/2017
1	Methionine (L-Methionine)FDA Link 12/2017
1	Methionine AdenosyltransferaseIBA 12/2017
1	Adenosine Triphosphate (ATP)IBA 12/2017
1	Niacinamide (Nicotinamide)FDA LinkGeneric 06/2010
1	Ammonium CompoundsIBA 06/2010
1	CalciumIBA 05/2008
1	Glutamic Acid (Glutamate)FDA Link 05/2008
1	Acetates (Acetic Acid Esters)FDA Link 03/2008
1	LipidsIBA 05/2006
1	Proteins (Proteins, Gene)FDA Link 06/2002

Therapy/Procedure

1	Traditional Medicine (Folk Remedies) 01/2021
1	Chinese Traditional Medicine (Traditional Chinese Medicine) 01/2021
1	Enzyme Replacement Therapy 02/2011